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A funnel plot is suggestive of the presence of most of the studies outside the plot, hence it is likely that significant publication bias is present DISCUSSION Obesity has severe health consequences, with each 5 kg/m 2 increase in BMI beyond the normal range linked to a 30% increase in mortality and a potential reduction in life expectancy by up to 10 years.[16] Conversely, significant weight loss is associated with metabolic and non-metabolic benefits

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The constitutively expressed copper- and zinc-containing SOD (Cu/Zn-SOD or SOD1) is a dimer that exists intracellularly in the cytoplasm but also in the nucleus and in peroxisomes