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Research status preclinical Sequence MRWQEMGYIFYPRKLR Molecular weight 2174.64 Da Molecular formula C101H152N28O22S2 Studied applications •Exercise mimetic: causes cells to behave as if exercise has occurred, with older mice doubling running capacity on treadmill tests •AMPK activation: potent activator of the 'metabolic master switch' AMP-activated protein kinase, increasing glucose uptake and fat burning •NAD+ and sirtuin elevation: increases NAD+ levels and activates SIRT1, metabolic cofactors critical for cell survival and energy metabolism •Insulin sensitivity: improves glucose uptake and insulin responsiveness in muscle and adipose tissue •Folate-methionine regulation: modulates folate and methionine metabolism, pathways connected to DNA methylation and cellular stress •Bioregulator association: centenarians maintain higher MOTS-c levels than shorter-lived peers