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Conversely, MITF itself has also been shown to directly induce the expression of PGC1α (Shoag et al., 2013), suggesting a positive feedback loop between these pathways supporting melanocyte differentiation (MITF) and mitochondrial biogenesis (PGC-1)
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Given the observed accumulation of mitochondrial GSH in breast cancer metastases and the selective essentiality of SLC25A39 in the screen, we focused on defining the role of mitochondrial GSH in metastasis
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