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Larger doses may produce serious or even life threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects

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Furthermore, mortality was found to be increased in a European population of relatively low selenium status (plasma selenium 89 µg/l) on long-term supplementation with 300 µg/d (as selenium-yeast) ( Reference Rayman, Winther and Pastor-Barriuso 111 )