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α1 selective agonist increases upright blood pressure by stimulating α1 receptors in both the arteriolar and venous vascular beds, thereby reducing orthostatic hypotension

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Brown algae ( Saccharina japonica ), through the polyphenol dieckol, regulates the TLR4/NLRP3 signaling pathway to suppress neuroinflammation, oxidative stress, and apoptosis, effectively counteracting the pro-inflammatory cytokine cascade associated with anxiety (29, 30)