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OS not only leads to the formation of oxidized DNA bases and strand breaks but can also induce de novo point mutations [142]
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Polygenic risk scores (PRS) incorporating PNPLA3, TM6SF2, and MBOAT7 can predict the likelihood of developing liver fat accumulation, inflammation and fibrosis and help to identify individuals at high risk of liver disease progression, particularly in situations where liver biopsy is not possible or practical [281]
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