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For example, the patients with mild to moderate depressive symptoms accompanied by irritable bowel syndrome (IBS) who were treated with Bifidobacterium longum NCC3001 had significantly improved depressive symptoms and quality of life scores compared with the placebo group, as well as improved responses to multiple brain regions (including the amygdala and the marginal frontal lobe) to negative emotional stimuli (Pinto-Sanchez et al., 2017)

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