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Enemas have been used for detoxification purposes for over 2,000 years, with references appearing in the ancient Egyptian Ebers Papyrus (circa 1550 BCE)
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In this report, we strategically designed double, and triple, mutants that combine the individual substitutions T94 2.61 I, E134 3.49 Q, and M257 6.40 Y known to lead to either dark and/or constitutive activity 13,14,15,16,17
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