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Research published in 2025 found that a protective enzyme called GPX4 declines in women with reduced ovarian reserve, and that blocking ferroptosis in animal models restored egg quality (Hu et al., FASEB Journal , 2025)
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The FDA placed it in 503A Category 2 ("may present significant safety risks") in 2023, effectively barring compounding pharmacies from using it, then removed it from that category in April 2026 after nominators withdrew their submission, without adding it to the approved Category 1 compounding list
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